Brain cells and Obesity – Have you lost control on your eating pattern? Nothing to worry much. Brain cells can control obesity from now on. In a very recent study attempted on mice, it has been found that a specific brain cell is capable of sending off signals that can stop eating behavior of someone. Richard Hugainr, director of John Hopkins University, claimed that when such cells delivered signals then mice have taken 25% less food on each day. So if such brain cells can boost up for sending anti obesity signals, then obesity problem can be solved easily. Now the question is how to boost up such cells?

Can Brain cells’ signal control ObesityJournal science has published the out comings of the study that elaborates of how brain cells can tell animals to stop eating further. If the same thing can be performed for human beings, then obesity won’t be a huge issue for anyone anymore. Para-ventricular nucleus is a small portion of the brain that is used for sending and receiving food related signals. During the research, when the catalyst remains silent, mice used to eat more and more compared to others. When this particular portion of the brain was inactive then the mice didn’t understand that they have consumed enough food, so no more food needed. So they continued eating more and more. Lagerlof, a graduate from Johns Hopkins University suggested that surely they have received a new mode of information receiver and if same thing can be applicable for homo sapiens then for this portion of brain some drugs can be invented.

Team of researchers identified cells in a small region of brain called para-ventricular nucleus, that was known to receive and send signals related to food intake and appetite. It is these signals that told the mice that they have had enough food, Huganir said.

When gene for OGT, biological catalyst responsible for several body functions, was silenced, the mice ended up eating more. Even though they consumed same meals as other mice, they ate much bigger portions. Also, when OGT is missing, the animal’s lost their ability to sense when they have had enough.
“These mice don’t understand that they’ve had enough food, so they keep eating,” said Olof Lagerlof, graduate student from Johns Hopkins University.

When the gene for OGT was silenced, the mice ate more. Although they consumed the same number of meals as normal mice, they ate bigger portions.

Also, the absence of OGT interfered with the animals’ ability to sense when they were full, suggesting that, OGT helps maintain synapses.

“These mice don’t understand that they’ve had enough food, so they keep eating,” said Olof Lagerlof, graduate student from Johns Hopkins University.

“We believe we have found a new receiver of information that directly affects brain activity and feeding behaviour, and if our findings bear out in other animals, including people, they may advance the search for drugs or other means of controlling appetites,” Lagerlof suggested.

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