HIV, TRUVADA – HIV was quite in recent years and the cases were decreasing day by day however this deadly virus decided to make a great comeback for itself. Different cases such as the virus developed a protection for the current medicines which prevents it, high raise in the patients and a conference held in Boston last week. HIV does not have that much death ratio just like it used to have in 80s however it is still among the diseases which can ruin the sufferers’ life. This also raised the popularity of the Truvada once again and new studies are being carried out about it.
When comparing the effectiveness of Truvada in men and women, researchers found that twice as much of this drug is required to prevent infection in vaginal and cervical tissue than in rectal tissue because fewer components can make it into those two types of tissue. Besides, women need a higher dose of Truvada given that the virus uses more DNA material for reproducing in vaginal and cervical tissue.
Women need more doses of Truvada than men to prevent HIV infection
Researchers used human cells in a test tube to measure the amount of DNA material in the cells and examine how much of Truvada was needed to prevent HIV infection in them. They then gave the drug to 47 healthy women and tested the medication levels and DNA material present in each of them after gathering samples of vaginal, cervical and rectal tissues.
Truvada, produced by Gilead, was approved by the FDA as a “pre-exposure prophylaxis” (PrEP) of HIV. The combination of two HIV drugs called tenofovir and emtricitabine was successful in clinical trials compared to a placebo, working to multiply inside T-cells or CD4 cells that play an important role in the fight against infections.
The blue pill is not always 100% effective
Dr. David Knox, an HIV expert, suggested that Truvada’s failure could have been caused by a rare transmission of an HIV 1 strain that resists to both emtricitabine and tenofovir. Other specialists say that the medication could have failed because of an inconsistent or sporadic intake, but the man infected said he religiously took the pill for two years.